| 1a | Clinical condition or Lower urinary tract infection (UTI) in non-pregnant women aged 16
situation to which this years to 64 years in the absence of current or recent fever (within past
PGD applies 48 hours) | Nitrofurantoin | 1.3 | Edit |
| 2a | Clinical condition or Shingles (herpes zoster) infection in adults aged 18 years and over.
situation to which this
PGD applies | Aciclovir | 1.1 | Edit |
| 2b | Clinical condition or Shingles (herpes zoster) infection in adults aged 18 years and over.
situation to which this
PGD applies | Valaciclovir | 1.1 | Edit |
| 3a | Localised non-bullous impetigo in children aged 1 year and over and adults who are systemically well and not at high risk of complications | Hydrogen Peroxide (Crystacide) | 1.1 | Edit |
| 3b | Clinical condition or Localised non-bullous impetigo in children aged 1 year and over and
situation to which this adults who are systemically well and not at high risk of complications.
PGD applies | Fusidic Acid | 1.0 | Edit |
| 3c | Clinical condition or Widespread non-bullous impetigo in children aged 1 year and over and
situation to which this adults who are systemically well and not at high risk of complications.
PGD applies | Flucloxacillin | 1.1 | Edit |
| 3d | Clinical condition or Widespread non-bullous impetigo in children aged 1 year and over and
situation to which adults, where flucloxacillin is not appropriate due to hypersensitivity
this PGD applies | Clarithromycin | 1.1 | Edit |
| 3e | Clinical condition or Widespread non-bullous impetigo in young people and adults aged 16
situation to which years and over who are pregnant, or where pregnancy is suspected and
this PGD applies where flucloxacillin is not appropriate due to hypersensitivity. | Erythromycin | 1.1 | Edit |
| 4a | Clinical condition or Infected insect† bite(s) and sting(s) in children aged 1 year and over and
situation to which this adults.
PGD applies
† As per NICE and NICE CKS guidance, the term “insect” includes those
with six legs (e.g. mosquitoes, gnats and flies) and those with eight legs
(e.g. spiders, mites and ticks). | Flucloxacillin | 1.1 | Edit |
| 4b | : “† As per NICE and NICE CKS guidance, the term “insect”
includes those with six legs (e.g. mosquitoes, gnats and flies) and those
with eight legs (e.g. spiders, mites and ticks).”
• Exclusion criterion amended from “Bite or sting occurred while travelling
outside the UK” to “Bite or sting occurred while travelling outside the UK
with concern of insect borne disease e.g. malaria, tick borne
encephalitis”
• Addition of:
• “Chloroquine or hydroxychloroquine
• Lomitapide
• Ivabradine
• Medicines where concomitant use with a strong CYP 3A4
inhibitor (i.e. clarithromycin) is contraindicated (e.g.
o Avanafil
o Dronedarone
o Eplerenone
o Finerenone
o Lercanidipine
o Lurasidone
o Naloxegol
o Quetiapine)
• Any other medicine where concomitant use with clarithromycin is
contraindicated” to “ | Clarithromycin | 1.1 | Edit |
| 4c | : “† As per NICE and NICE CKS guidance, the term “insect”
includes those with six legs (e.g. mosquitoes, gnats and flies) and those
with eight legs (e.g. spiders, mites and ticks).”
• Exclusion criterion amended from “Bite or sting occurred while travelling
outside the UK” to “Bite or sting occurred while travelling outside the UK
with concern of insect borne disease e.g. malaria, tick borne
encephalitis”
• Addition of:
o “Lomitapide
o Medicines where concomitant use with a moderate CYP 3A4
inhibitor (i.e. erythromycin) is contraindicated (e.g.
▪ Lercanidipine
▪ Ivabradine
▪ Quetiapine)
Version: 1.1
Reference Number: 4c
Valid from: 01/10/2025
Review date: 30/04/2027
Expiry date: 30/09/2028
o Any other medicine where concomitant use with erythromycin is
contraindicated” to “ | Erythromycin | 1.1 | Edit |
| 5a | Clinical condition or Acute sore throat due to suspected streptococcal infection in children aged
situation to which 5 years and over and adults.
this PGD applies | Phenoxymethylpenicillin | 1.1 | Edit |
| 5b | Clinical condition or Acute sore throat due to suspected streptococcal infection in children
situation to which this aged 5 years and over and adults, where phenoxymethylpenicillin is not
PGD applies appropriate due to hypersensitivity. | Clarithromycin | 1.1 | Edit |
| 5c | Clinical condition or Acute sore throat due to suspected streptococcal infection in young
situation to which this people and adults aged 16 years and over who are pregnant, or where
PGD applies pregnancy is suspected and where phenoxymethylpenicillin is not
appropriate due to hypersensitivity. | Erythromycin | 1.1 | Edit |
| 6a | Clinical condition or Acute sinusitis (rhinosinusitis) in children aged 12 years and over and
situation to which adults.
this PGD applies | Fluticasone Furoate | 1.1 | Edit |
| 6b | Clinical condition or Acute sinusitis (rhinosinusitis) in children aged 12 years and over and
situation to which this adults.
PGD applies | Mometasone Furoate Monohydrate | 1.1 | Edit |
| 6c | Clinical condition or Acute bacterial sinusitis (rhinosinusitis) in children aged 12 years and
situation to which this over and adults.
PGD applies | Phenoxymethylpenicillin | 1.1 | Edit |
| 6d | Clinical condition or Acute bacterial sinusitis (sinusitis) in children aged 12 years and over
situation to which this and adults where phenoxymethylpenicillin is not appropriate due to
PGD applies hypersensitivity. | Clarithromycin | 1.1 | Edit |
| 6e | Clinical condition or Acute bacterial sinusitis (rhinosinusitis) in children 12 years and over and
situation to which this adults where phenoxymethylpenicillin is not appropriate due to
PGD applies hypersensitivity. | Doxycycline | 1.1 | Edit |
| 6f | Clinical condition or Acute bacterial sinusitis (sinusitis) in adults 16 years and over who are
situation to which this pregnant or where pregnancy is suspected and where
PGD applies phenoxymethylpenicillin is not appropriate due to hypersensitivity. | Erythromycin | 1.1 | Edit |
| 7a | Clinical condition or Local symptomatic relief of pain from acute otitis media (AOM) in
situation to which this children aged 1 year and over and young people (under 18 years of
PGD applies age). | Otigo | 1.1 | Edit |
| 7b | Clinical condition or Acute otitis media in children aged 1 year and over and young people (under
situation to which this 18 years of age)
PGD applies | Amoxicillin | 1.1 | Edit |
| 7c | Clinical condition or Acute otitis media in children aged 1 year and over and young people
situation to which this (under 18 years of age), where amoxicillin is not appropriate due to
PGD applies hypersensitivity. | Clarithromycin | 1.1 | Edit |
| 7d | Clinical condition or Acute otitis media in young people aged 16 or 17 years of age who are
situation to which this pregnant or where pregnancy is suspected and where amoxicillin is not
PGD applies appropriate due to hypersensitivity. | Erythromycin | 1.1 | Edit |